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15 More Medicare Drugs Are Getting Price Cuts in 2027 - Find Out If Yours Is on the List

Some expensive drugs will see costs fall by more than 80%.

By Chris Kissell , Edited by Calista Headrick

Updated Sept. 21, 2026

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Beginning next year, Medicare beneficiaries will see prices fall for 15 key medications. Late in 2025, the U.S. Centers for Medicare & Medicaid Services (CMS) announced the list of drugs that would receive negotiated price cuts kicking in on Jan. 1, 2027.

The cuts will save Medicare between $8.5 billion and $12 billion annually and provide $685 million in out-of-pocket relief to millions of beneficiaries. Find out which drugs made the cut and whether the price reductions will help you keep more of your money.

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Ozempic; Rybelsus; Wegovy

2027 price: $274
Percentage reduction: 71%

These drugs have gained fame for their role in managing overweight and obesity. However, they also are used to treat Type 2 diabetes and cardiovascular disease. The 2024 list price was $959. In 2027, that will drop to $274 for a 30-day supply of the prescription.

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Trelegy Ellipta

2027 price: $175
Percentage reduction: 73%

Trelegy Ellipta is used to treat both asthma and chronic obstructive pulmonary disease. The 2024 list price was $654.

Xtandi

2027 price: $7,004
Percentage reduction: 48%

Xtandi is used to treat prostate cancer and will cost consumers $7,004 in 2027. The 2024 list price was a shocking $13,480.

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Pomalyst

2027 price: $8,650
Percentage reduction: 60%

Pomalyst will see a 60% price reduction, down to $8,650, compared to $21,744 in 2024. It is used to treat Kaposi sarcoma and multiple myeloma, both of which are types of cancer.

Ofev

2027 price: $6,350
Percentage reduction: 50%

A treatment for idiopathic pulmonary fibrosis, Ofev carried a 2024 list price of $12,622 — more than twice what patients will pay in 2027.

Ibrance

2027 price: $7,871
Percentage reduction: 50%

At $15,741 in 2024, Ibrance — a breast cancer treatment — will see its price cut in half under the new negotiated rate.

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Linzess

2027 price: $136
Percentage reduction: 75%

The 2024 list price for Linzess was $539. The drug, which treats chronic idiopathic constipation and irritable bowel syndrome with constipation, will drop by 75% in 2027.

Calquence

2027 price: $8,600
Percentage reduction: 40%

Calquence treats two blood cancers: chronic lymphocytic leukemia/small lymphocytic lymphoma and mantle cell lymphoma. Its 2024 list price of $14,228 will fall 40% by 2027.

Austedo; Austedo XR

2027 price: $4,093
Percentage reduction: 38%

Used for chorea in Huntington's disease and tardive dyskinesia, these drugs had a 2024 list price of $6,623 before the 38% reduction takes effect.

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Breo Ellipta

2027 price: $67
Percentage reduction: 83%

Few drugs on this list saw steeper cuts. Breo Ellipta, which treats asthma and chronic obstructive pulmonary disease, will drop from a 2024 list price of $397 to just $67.

Xifaxan

2027 price: $1,000
Percentage reduction: 63%

Prescribed for both hepatic encephalopathy — a brain dysfunction tied to liver disease — and irritable bowel syndrome with diarrhea, Xifaxan's 2024 price of $2,696 will fall by nearly two-thirds.

Vraylar

2027 price: $770
Percentage reduction: 44%

The 2024 list price for Vraylar was $1,376. The medication, used to manage bipolar 1 disorder, major depressive disorder, and schizophrenia, will be nearly halved by 2027.

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Tradjenta

2027 price: $78
Percentage reduction: 84%

At $488 in 2024, Tradjenta was already a relatively affordable Type 2 diabetes treatment. Its 84% price cut brings it down to $78, one of the sharpest reductions on the list.

Janumet; Janumet XR

2027 price: $80
Percentage reduction: 85%

These Type 2 diabetes drugs had a combined 2024 list price of $526. The 85% reduction (the largest of any medication negotiated) brings them to $80 in 2027.

Otezla; Otezla XR

2027 price: $1,650
Percentage reduction: 65%

Treating oral ulcers in Behçet's disease, plaque psoriasis and psoriatic arthritis, these drugs will drop from $4,722 in 2024 to $1,650. That's a 65% reduction.

Another way Medicare drugs are becoming cheaper

Medicare drugs also have become cheaper for some people thanks to a separate change that went into effect this year.

Beginning in 2026, there is a $2,100 cap on out-of-pocket prescription costs on covered prescription drugs for everyone with Medicare Part D coverage. This replaces the old untapped catastrophic coinsurance of 5%, which ran through the end of the calendar year.

The new cap means Medicare beneficiaries with very expensive prescription drugs are likely to save a lot of money compared to previous years.

How to save more money on Medicare drugs

It's important to note that the prices on this list are the maximum fair prices manufacturers must charge Medicare itself. That means the cost you pay will depend on your specific plan.

If you have Medicare Part D and want to learn more about the medications on this list, visit the CMS website. You can also use the Medicare Plan Finder to compare Medicare Advantage, Medigap and Medicare Part D plans.

Bottom line

The Medicare Annual Enrollment Period is slated for Oct. 15 through Dec. 7, making it the right time to investigate your options and to see if it makes sense to switch to a new plan.

Many potentially life-saving medications come with large price tags. The drugs on this list will become more affordable in 2027, helping millions of retirees to eliminate some money stress. If you take these drugs or believe they might be helpful in treating your condition, consult with a physician.

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